Alexander Haindrich

PhD student

Molecular Plant Physiology

+41 31 684 49 18
27, Brückentrakt, Parterre
Postal Address
University of Bern
Institute of Plant Sciences
Altenbergrain 21
3013 Bern

Research Interests

My PhD study is focused on the functional characterization of the amino acid transporters of Trypanosoma brucei. The different demand for amino acids of T. brucei compared to its mammalian host makes amino acid transporters potential targets for new drug developments, but also due to their location on the cell surface the transporters themselves act as an possible entry point for drugs into the parasite, naming just two out of many reason to study these proteins.
For the biophysical characterization of the transporters we use heterologous model systems like Saccharomyces cerevisiae or Xenopus laevis oocytes, but we also investigate the direct function of the transporters in in vitro cultures of the bloodstream and procyclic stage of T. brucei.

Number of items: 1.

Journal Article

Mathieu, Christoph; Pereira de Macêdo, Juan; Hürlimann, Daniel; Wirdnam, Corina; Haindrich, Alexander; Suter, Marianne; González Salgado, Amaia; Schmidt, Remo; Inbar, Ehud; Mäser, Pascal; Bütikofer, Peter; Zilberstein, Dan; Rentsch, Doris (2017). Arginine and Lysine Transporters Are Essential for Trypanosoma brucei. PLoS ONE, 12(1), e0168775. Public Library of Science 10.1371/journal.pone.0168775

This list was generated on Sat Jun 22 09:50:41 2024 CEST.


Haindrich, Alexander C.; Boudová, Michala; Vancová, Marie; Peña Diaz, Priscila; Horáková, Eva; Lukeš, Julius (2017) The intermembrane space protein Erv1 of Trypanosoma brucei is essential for mitochondrial Fe-S cluster assembly and operates alone. Molecular and Biochemical Parasitology, 214, pp. 47–51. 10.1016/j.molbiopara.2017.03.009

Pyrih, Jan; Pyrihova, Eva; Kolisko, Martin; Stojanovova, Darja; Basu, Somsuvro; Harant, Karel; Haindrich, Alexander C.; Dolezal, Pavel; Lukes, Julius; Roger, Andrew; Tachezy, Jan (2016) Minimal cytosolic iron-sulfur cluster assembly machinery of Giardia intestinalis is partially associated with mitosomes. Molecular Microbiology, 102(4), pp. 701-714. 10.1111/mmi.13487

Basu, Somsuvro; Netz, Daili J.; Haindrich, Alexander C.; Herlerth, Nils; Lagny, Thibaut J.; Pierik, Antonio J.; Lill, Roland; Lukes, Julius (2014) Cytosolic iron-sulphur protein assembly is functionally conserved; essential in procyclic; bloodstream Trypanosoma brucei. Molecular Microbiology, 93(5), pp. 897-910. 10.1111/mmi.12706